Updated: Mar 3, 2020
With Coronavirus spiraling out of control across the world, most people are loading up on all sorts of Vitamins, Supplements, and Products in an attempt to provide them with the most protection. And though this isn’t a bad idea, there are a lot of things out there that are likely to waste money and not be very effective based on their method of manufacture. There are some supplements that are better than others, though, and I thought it would be a good idea to share my opinions on this topic with our reader base and research clients in case they were interested.
Based on NIH Data, IDF Data, Clinical Experience, User Experience, and my own experience, the most important supplement to maintain good health and wellness year round and to develop a natural resistance to viruses, bacterial infections, and other chronic health problems is Liposomal Vitamin C made with Ascorbic Acid such as that made here at the Phoenix Aurelius Research Academy. Historically speaking, we offer ‘Spagyri-Somal’ vitamin C four times a year in limited batches, which is an Ascorbic Acid Liposomal Vitamin C formulation used in Clinical Research except that we switch out the Ethanol for a Spagyric Tincture of Lemon Peel to add extra beneficial bioflavonoids and synergistic constituents to make it more effective. All throughout 2018 and 2019, IDF analysis has repetitively demonstrated that the Spagyri-Somal Vitamin C we make for our Research Clients dwarfs the General Vitality, Physical Purity, Energetic purity, and literally every other category we test for when compared to products made available by other commercial manufacturers. However, in the face of a viral threat such aCoViD 19, our production rate of 3-5 gallons every three to four months makes our product unavailable to the majority of our regular research clients, let alone a grander public, so we’re now manufacturing Ascorbic Acid Liposomal Vitamin C without the Spagyric Tincture of Lemon Peel to provide an alternative to clients who want a more affordable and more regularly-available solution.
In every study available by the NIH that we are aware of, L-Ascorbic Acid was used, not Sodium Ascorbate, in order to make Liposomal Vitamin C Solution to test efficacy in vitro and in vivo. Sodium Ascorbate is what is used by every company manufacturing it for retail sale today, though. So that begs the question: Why are they making this with Sodium Ascorbate? There really is no price difference between Sodium Ascorbate and L-Ascorbic Acid, so it’s not for purely economic reasons. And also it’s more difficult to create a buffered form of Ascorbate such as Calcium or Sodium Ascorbate because it requires Ascorbic Acid and a mineral such as Calcium Chloride or Sodium Chloride in order to make it. After tons of research, I have to conclude that their decision to use Sodium Ascorbate is made largely because on its own, Sodium Ascorbate is more readily absorbable in higher quantities than is Ascorbic Acid, largely because Ascorbic Acid on its own presents various pH complications that can disrupt the stomach and cause a flushing of the colon, resulting in diarrhea.
At this point, we need to distinguish between methods of administration and also delivery mechanisms otherwise there is going to be some confusion. For instance, Ascorbic Acid in its raw, non-liposomal form can cause stomach upset because of differences in pH due to the presence of direct acid to the digestive tract like I just alluded to. As a result of this, scientists were prompted to figure out a better delivery system that doesn’t affect the digestive system in the same way. The way they did this was to create an acid-base reaction using Ascorbic Acid and Sodium Bicarbonate. Combining an Acid [like Ascorbic Acid] with a base [such as Sodium Bicarbonate] creates a chemical reaction that prompts the release of Carbon Dioxide as a gas, leaving a solution Sodium Ascorbate. If you combined Sodium bicarbonate with Glacial Acetic Acid [or it’s diluted form of Vinegar], the same thing would happen, except you would be left with Sodium Acetate. Most of you have already experienced that in grade school science fairs when seeing a ‘Volcano’ project. What this does in terms of digestion is neutralize the pH and therefore make Sodium Ascorbate more readily digestible without upset stomach caused by Ascorbic Acid.
Bottom Line is this: between ingesting Ascorbic Acid or Sodium Ascorbate powdered supplements on their own, it is probably better to take Sodium Ascorbate if you want to get as much Vitamin C intake as you possibly can [unless you are on a sodium restricted diet].
That said, when Ascorbic Acid is put into a liposomal solution with a Phospholipid, such as Sunflower Lecithin, it can be taken at extremely high application rates without having ANY of the stomach discomfort or colon flushing symptoms associated with Ascorbic Acid on its own. This, from a formulation perspective, actually causes Sodium Ascorbate to become more or less obsolete to use in Liposomal Solution, especially because Sodium Ascorbate has to be converted through biochemical digestive process into Ascorbate while removing the Sodium. Ascorbic Acid Liposomal Vitamin C has fewer biochemical conversions necessary, and so creates a higher quality Liposomal Vitamin C, which is why I deduced that most NIH Clinical Studies use it instead of Sodium Ascorbate. As a result, between Ascorbic Acid Liposomal Vitamin C and Sodium Ascorbate Liposomal Vitamin C, it makes more sense from a biochemical conversion level and cellular bioavailability level to use Ascorbic Acid in the Liposomal Solution. To go along with my theory, there are a few risks of using Sodium Ascorbate in a Liposomal Solution that are not present with L-Ascorbic Acid. Sodium Ascorbate-based Liposomal Vitamin C Solutions contain approximately 120 mg of sodium per 5 mL serving. This sodium becomes CELLULARLY bioavailable, and sodium levels are known to create an imbalance of other minerals in the cellular system that are necessary for maintaining cellular homeostasis. There is not any conclusive data showing that Sodium Ascorbate-containing Liposomal Solution is safe in high dosages or that it actually is beneficial to the cells when taken in levels above the suggested 5 - 5.7 mL per day. If used effectively as a viral preventative or to lessen the duration or intensity of Respiratory Viral Symptoms, a dosage of between 20-90 mL per day is actually more in line with what would need to be consumed. That would put between 480 mg - 2160 mg of Sodium into the body. Keep in mind that the American Heart Association recommends no more than 2,300 milligrams (mg) a day and actually suggests an ideal limit of no more than 1,500 mg per day for most adults. So taking high dosages of Liposomal Vitamin C made with Sodium Ascorbate could cause various cardiovascular complications such as High Blood Pressure + Rupturing Blood Vessels, but that’s just scraping the tip of the iceberg.
Among the other risks of taking high doses of Sodium are Renal Complications, Genito-Urinary Complications, and Neurological Complications, which could include Stroke, Seizure, and more. Many users of Sodium Ascorbate-containing Liposomal Vitamin C report having to frequently urinate or having low back pain, which corroborate the data pertaining to high sodium level symptoms. It seems to me that taking the High-Dose Liposomal Vitamin C Application Rates that are used in NIH and other Clinical studies to study antiviral effects, Cancer-destroying effects, etc; would inherently cause other side effects that are undesirable because of the Cellular Bioavailability. Furthermore, with prolonged usage at high rates, it could create various Cytotoxicity issues because of resulting imbalances of other important Cell Salts and Minerals, namely creating imbalances of Sodium to the ratios of Potassium and Magnesium.
At this point in history, there are no known studies performed using Sodium Ascorbate Liposomal Vitamin C at high levels to show its efficacy or safety in the same way that there are Ascorbic Acid Liposomal Vitamin C studies. That said, both forms are perfectly beneficial if taken in low application rates of only 5mL once daily. But for anti-viral, anti-cancer, anti-sepsis, and other applications, it seems common sense given all the data that taking up to 30 mL 3 times daily as can safely be applied using Ascorbic Acid Liposomes could potentially pose some serious issues if using Sodium Ascorbate Liposomes because of the amount of Sodium being ingested.
All of this data was taken into consideration when we performed the R&D on our product back in late 2014. We split tested both Ascorbic Acid and Sodium Ascorbate in formulations to determine which we liked best. The reaction was unanimous among our trial testers who decided that flavor was far better using Ascorbic Acid than the Salty/Sour flavor of Sodium Ascorbate. Furthermore, high application rates of Sodium Ascorbate caused some trial testers to urinate frequently and to have high blood pressure. Both organoleptically and in terms of side effects, we have decided to create the Liposomal Vitamin C for our Research Academy using L-Ascorbic Acid instead of Sodium Ascorbate.
Beyond just the use of Sodium Ascorbate or Ascorbic acid, our product is profoundly pure. If you look at all other manufacturers, you will find fillers, binders, preservatives, flavoring agents, and undesirable ingredients in the formulation. The most popular brands use things like Vegetable Glycerin, Xanthan Gum, Citric Acid, Citrus Flavoring Agents, and others besides. Our Liposomal Vitamin C is made using only 4 Organic Ingredients and does not contain any preservatives, fillers, binding agents, or flavoring agents. Again, because of the Cellular Bioavailability, you don’t want Citrus Flavorings, Glycerin, or Citric Acid from Genetically Modified Molds being delivered directly to you cells; it’s just not a sensible policy for cellular homeostasis. Furthermore, there are no manufacturers that we are currently aware of who are manufacturing 100% organic ingredients the way we do. This increases our costs of materials, but it also creates a product that is unparalleled in its purity and the IDF data we have pulled throughout 2019 has demonstrated as much.
In conclusion, even though there are lots of different manufacturers of Liposomal Vitamin C whose products are widely available, and even less expensive than ours, we feel that a Liposomal Solution made with Organic Ingredients and Ascorbic Acid devoid of any fillers, binders, preservatives, or flavoring agents is far superior to the products commercially available today. The downside of our product is that it is more expensive and produced in small batches of 3-5 gallons to control purity and our product is only available to those who are funding our research due to legal restrictions. That said, organoleptic testing and user experience regularly report that our product is infinitely more effective and tasty than the commercial brands, and can be taken in much larger quantities without any adverse effects or undesirable symptoms.
To prevent viral infections and invasion of foreign pathogens, I suggest a more comprehensive routine. Along with our Liposomal Vitamin C at the application rate of 3000+ mg/day per healthy adult, I also strongly feel that there should be a few other accompanying Vitamins and Minerals that need to be consumed either through diet or supplementation. These would be 2000 IU of Vitamin D per day, 400 mg Magnesium per day, 20mg of Zinc per day, and 100mcg of Selenium per day. These application rates are ONLY applicable to healthy adults between 115 lbs and 215 lbs. For those adults above or below that weight range, a modified protocol is probably necessary, as it is for Children, as well. In clinical studies, Vitamin C, Vitamin D, Magnesium, Zinc, and Selenium all have proven to strengthen the immune system and protect against viruses.
The same vitamins and minerals also help to obliterate viruses in vitro and in vivo if taken consistently, which results in a drastic amelioration of the intensity and duration of the symptoms of respiratory viruses. If Infected with Coronavirus, I would personally increase the intake of the Liposomal Vitamin C to 18,000 mg per day, take up to 5000 IU of Vitamin D per day, and keep the other minerals at their same rate. That said, I would personally also add a few things: I would include Vitamin A in the amount of 1500 mcg daily for respiratory support, 2 drops of Lugol’s 2% Iodine in a solution of 4oz of Water mixed with 1 TBSP of Apple Cider Vinegar twice to three times a week for 2 weeks, and take Osha Root Spagyric Tincture in the amount of 15 drops up to 10 times daily depending on the severity of the symptoms.
I would also regularly include 2-4 10oz+ bottles of Coconut Water [which contain balanced ratios of Potassium to Magnesium for ideal Cellular Health] and eat foods to which I have added Grey Celtic Sea Salt to ensure proper balance of bioavailable Sodium: Potassium: Magnesium. Depending on symptoms, I may also include Cordyceps Militaris or Inala Leaf Spagyric Tinctures to aid oxygenation to treat symptoms of hypoxia caused by respiratory decline. I would likely include Lungwort Tea and Chew on Whole Organic Cloves to break up mucus, and incorporate European or Black Elderberry Juice/Syrup or a Spagyric Tincture of the same to fight the viral conditions as well. Depending on the circumstances, I would also likely take 15-30 drops of Licorice Root Spagyric Tincture to aid with Respiratory Support. This protocol, while safe for the majority of the population, could have very serious contraindications or side effects based on lifestyle, medications, genetic defects, or other pre-existing conditions of the person taking them. So please realize that this is what I would do, and these things may not work the same for you. Always perform your research and study the Contraindications and Side Effects of every herb, vitamin, or mineral before you self-prescribe a protocol. And if possible, check with a few licensed medical professionals to gather their opinions so you can weigh that into your calculations as well.
Because the majority of this article is based on Liposomal Vitamin C, I wanted to provide some resources for those interested to perform some deeper research. I have also included a list of resources concerning Vitamin D, Magnesium, Zinc, and Selenium being effective antiviral protection.
My Data Based on IDF Analysis, User Experience, and Clinical Data of Liposomal Vitamin C:
Our Liposomal Vitamin C only contains the following 4 ingredients:
Distilled Water [Produced Myself]
96% Organic Cane Ethanol [Made in Paraguay]
L-Ascorbic Acid powder derived from Organic Camu Camu and/or Acerola Cherry [Made in USA]
Organic Sunflower Lecithin Powder [Grown and Produced in The Netherlands]
Application Rates Are As Follows:
Our Liposomal Vitamin C contains .2 gms (200 mg) of Vitamin C/mL of Liposomal Solution. 30mL (1 fl oz) provides 6 grams (6000 mg) of Vitamin C at between 91% and 95% Cellular Bioavailability.
For Healthy Persons in Non-Toxic Environment: 2-5ml 2x daily
For Healthy Person in Toxic Environment: 15mL 2x daily
For Healthy Athlete in Non-Toxic Environment: 10ml 2x daily
For Healthy Athlete in Toxic Environment: 30mL 2x daily
For Persons with Minor Infections: 15ml 3x daily
For Persons with Major Infections: 20ml 3x daily
For Persons with Cancers: 30ml 3x daily
Basic Safety Data:
Though there are absolutely no side effects in ordinarily healthy individuals for any dose of Liposomal Vitamin C because of its unique mechanism of delivery, there are a few safety precautions that a person ought to keep in mind to ensure the supplement is being used in the safest and most responsible way possible. To the best of my knowledge, this safety data is not discussed openly due to the commercial surge of popularity of this method of administration. Although it would be rare to experience symptoms if taking standard application rates of less than 10mL twice daily for periods of one month or less, it is feasibly possible to develop long standing problems with daily use at or above those application rates if the following are not taken into consideration:
1. Those with iron overload should understand that vitamin C increases the absorption of iron into the body, especially in the heart where it can cause problems. Ferritin levels should ideally be no more than 150 (in adult women) and 250 – 300 (for adult men). If you are above those levels, donating blood would be a great idea. Also, waiting 2-3 hours after taking the liposomal vitamin C before eating red meat or anything else that is high in HEME iron is STRONGLY suggested if iron levels are higher than the aforementioned numbers.
2. Phospholipids derived from Sunflower Lecithin are very rich in Omega 6 fatty acids, while not so rich in Omega 3 fatty acids. Those who do not eat diets rich in Omega 3 fatty acids may wish to supplement with Hemp Seed Oil, Fish Oil, Cod Liver Oil, or incorporate foods rich in Omega 3 fatty acids as an imbalance of Omega 3 fatty to Omega 6 fatty acids are one known contributing cause to cardiovascular diseases, including atherosclerosis, heart attack, and stroke.
1. One of the contraindications for vitamin C usage, regardless of its form or method of application, is a glucose-6-phosphate dehydrogenase (G6PD) deficiency. This is an inherited condition where the individual doesn’t have the G6PD enzyme. G6PD helps the body to function normally and very high doses of vitamin C infusions or very high doses of vitamins C and/or D pose a possibility of causing hemolytic anemia. A G6PD deficiency is an extremely rare situation, but should be tested before taking a high dose of IV vitamin C or Liposomal Vitamin C if any symptoms of G6PD deficiency are present.
2. Other contraindications would include allergens to the liposomal compounds, such as sunflower lecithin, and/or allergies either to Sugar Cane, Molasses, Treacle, or to Ethanol as this product contains Cane Ethanol. Individuals who are pregnant, young children, and/or taking blood thinning medications [whether over the counter or prescription medications] should use smaller dosages based on body weight and physician recommendations. My application rate schedule above is based on a full grown adult of between 115 lbs to 215lbs. Those who are very tall or rotund and thus exceed that weight may consider increasing their application rate or dosage per application, though exceeding 30mL 3 times a day is usually not necessary regardless of the weight of an individual with the exception of advanced cancer application rates. It is always advisable to discuss vitamin C therapy with a trusted medical provider before beginning a Vitamin C protocol– although most doctors have very little experience with this.
Resources Demonstrating Anti-Viral Activity of Vit C:
Hickey S, Saul AW (2015) Vitamin C: The real story. Basic Health Pub. ISBN-13: 978-1591202233.
Yejin Kim, Hyemin Kim, Seyeon Bae et al. (2013) Vitamin C is an essential factor on the anti-viral immune responses through the production of interferon-α/β at the initial stage of influenza A virus (H3N2) infection. Immune Netw. 13:70-74.
Liposomal Vitamin C Resources:
Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia–Reperfusion Injury [Pay Attention to everything in this article this one because this deals with Hypoxia, which is a side effect of most respiratory illnesses due to decreased respiratory capacity]
[ My clinical opinion is that one gram of properly-produced and orally-ingested liposome-encapsulated vitamin C is as or more effective than 5 to 10 grams of vitamin C given intravenously, for an acute viral syndrome. - Dr. Thomas E Levy]
[Liposomal vitamin C isn’t associated with any digestive discomfort, even at high dosages. Some (conventional) vitamin C supplements are associated with causing digestive discomfort, especially when taken at high dosages.]
[Results: Preliminary investigations of the effects of liposomal and standard formulation ascorbate showed that blood plasma levels in excess of the previously assumed maximum of 220 µm L−1 are possible. Large oral doses of liposomal ascorbate resulted in plasma levels above 400 µm L−1.]
[The side-effects reported for Vitamin C in powdered form include indigestion and mild diarrhoea in some people and this depends on each person's tolerance level to Vitamin C passing through the digestive tract. As it is mildly acidic it may give some people a mild upset. However, Vitamin C taken in its liposomal form eliminates these side effects due to the way it is formulated. The liposomes in which Vitamin C is encapsulated makes them insoluble and it is this lack of solubility that makes them impervious to stomach acids and bile salts. It also gives them quick and easy access into the bloodstream and enables them to slip across cell membranes as they quickly and safely transport nutrients to their intended destination. Those who take this superior form of Vitamin C do not report mild upsets of the stomach and mention the tangible difference in the health benefits.]
Other Resources on Vitamin C:
Resources for Vitamin D, Magnesium, Zinc, and Selenium:
Cannell JJ, Vieth R, Umhau JC et al. (2006) Epidemic influenza and vitamin D. Epidemiol Infect. 134:1129-1140. https://www.ncbi.nlm.nih.gov/pubmed/16959053.
Cannell JJ, Zasloff M, Garland CF et al. (2008) On the epidemiology of influenza. Virol J. 5:29. https://www.ncbi.nlm.nih.gov/pubmed/16959053.
Ginde AA, Mansbach JM, Camargo CA Jr. (2009) Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 169:384-390. https://www.ncbi.nlm.nih.gov/pubmed/19237723.
Martineau AR, Jolliffe DA, Hooper RL et al. (2017) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 356:i6583. https://www.ncbi.nlm.nih.gov/pubmed/28202713.
Urashima M, Segawa T, Okazaki M et al. (2010) Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 91:1255-60. https://www.ncbi.nlm.nih.gov/pubmed/20219962.
von Essen MR, Kongsbak M, Schjerling P et al. (2010) Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol. 11:344-349. https://www.ncbi.nlm.nih.gov/pubmed/20208539.
Dean C (2017) Magnesium. OMNS, http://www.orthomolecular.org/resources/omns/v13n22.shtml
Dean C. (2017) The Magnesium Miracle. 2nd Ed., Ballantine Books. ISBN-13: 978-0399594441.
Levy TE (2019) Magnesium: Reversing Disease. Medfox Pub. ISBN-13: 978-0998312408
Fraker PJ, King LE, Laakko T, Vollmer TL. (2000) The dynamic link between the integrity of the immune system and zinc status. J Nutr. 130:1399S-406S. https://www.ncbi.nlm.nih.gov/pubmed/10801951.
Liu MJ, Bao S, Gálvez-Peralta M, et al. (2013) ZIP8 regulates host defense through zinc-mediated inhibition of NF-кB. Cell Rep. 3:386-400. https://www.ncbi.nlm.nih.gov/pubmed/23403290.
Mocchegiani E, Muzzioli M. (2000) Therapeutic application of zinc in human immunodeficiency virus against opportunistic infections. J Nutr. 130:1424S-1431S. https://www.ncbi.nlm.nih.gov/pubmed/10801955.
Shankar AH, Prasad AS. (1998) Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr. 68:447S-463S. https://www.ncbi.nlm.nih.gov/pubmed/9701160.
Beck MA, Levander OA, Handy J. (2003) Selenium deficiency and viral infection. J Nutr. 133:1463S-1467S. https://www.ncbi.nlm.nih.gov/pubmed/12730444.
Hoffmann PR, Berry MJ. (2008) The influence of selenium on immune responses. Mol Nutr Food Res. 52:1273-1280. https://www.ncbi.nlm.nih.gov/pubmed/18384097.
Steinbrenner H, Al-Quraishy S, Dkhil MA et al. (2015) Dietary selenium in adjuvant therapy of viral and bacterial infections. Adv Nutr. 6:73-82. https://www.ncbi.nlm.nih.gov/pubmed/25593145.
6. Klenner FR. The treatment of poliomyelitis and other virus diseases with vitamin C. J South Med Surg 1949, 111:210-214. http://www.doctoryourself.com/klennerpaper.html.
7. Cathcart RF. The method of determining proper doses of vitamin C for treatment of diseases by titrating to bowel tolerance. Australian Nurses J 1980, 9(4):9-13. http://www.doctoryourself.com/titration.html